Clinical Publications & Research
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Flexineb and Nuclear Scintigraphy
Nuclear scintigraphy is a helpful diagnostic modality generally used, in horses, to look at radioisotope uptake in bone.
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Management of an ulcer on the epiglottis by nebulising BIOPRO-PLUS
After being claimed, a filly is presented with an intermittent, non-productive cough that shortly thereafter developed a mucopurulent exudate.
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Inhalation with NDS27 attenuates pulmonary
RECURRENT airway obstruction (RAO) or heaves is a chronic respiratory disease that affects mature horses. It is characterised by neutrophilic inflammation and delayed neutrophilic apoptosis (Turlej and others 2001) leading to lower airway inflammation, bronchocon- striction and mucus accumulation.
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NDS27, a hydrosoluble form of curcumin, modulates neutrophil activation in a horse model of LPSinduced lung neutrophilia
Aim: To assess the effects of inhalation of a hydrosoluble formof curcumin derivate, NDS27 (2), in a horse model of LPS inducedlung neutrophilia.
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Pharmacokinetics, pulmonary disposition and tolerability of
Aim: To compare the disposition of liposomal gentamicin (LG) and free gentamicin (FG) in the plasma, pulmonary epithelial lining fluid and bronchoalveolar cells of healthy foals after i.v. administration or by nebulisation, and to assess the tolerability of the drug after repeated i.v. dosing.
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Clinical Case Report: Flexineb Use with Quarter Horse
Dr. Kerstin Fischer Veterinary Surgeon, specialist vet for horses: Use of inhalation therapy in show Quarter Horse, undertaken using the Nortev Flexineb inhaler.
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Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation
Chronic inflammation and airway remodelling are characteristics of chronic obstructive pulmonary disease (COPD). Hyaluronan (HA) is an extracellular matrix compound with proinflammatory activity. HA levels in induced sputum from patients with COPD were measured and related to local inflammation. The expression of hyaluronan synthase 2 (HAS2) and hyaluronidase 2 (HYAL2) was analysed in lung tissue.
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Use of inhalation therapy in show Quarter Horse, undertaken using the Nortev Flexineb inhaler
The horse was known to our hospital for a few years as a patient with a recurring cough. He suffered from allergic bronchitis, which always got worse in the spring.
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Inhalation Therapy in Horses
Inhalation therapy in horses can be accomplished with nebulizers or pressured metered dose inhalers.
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Pulmonary pharmacokinetics of desfuroylceftiofur acetamide after nebulisation or intramuscular administration of ceftiofur sodium to weanling foals
Aim: To compare concentrations of desfuroylceftiofur acetamide (DCA) in plasma and pulmonary epithelial lining fluid (PELF) of foals after nebulisation or i.m. administration of ceftiofur sodium and to determine if nebulisation of ceftiofur sodium induces airway inflammation.
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Hyaluronan in Respiratory Injury and Repair
Over the past two decades, much of the research on the cellular and biochemical reactions to injurious agents of the lung has focused on specific cells and cytokines and their appearance or disappearance in the alveolar milieu.
